Medical staff were seen at Maradona's house on Wednesday as the soccer icon was taken to hospital amid suggestions that he had suffered a cardiac arrest.
The 1986 World Cup winner underwent brain surgery at the start of this month and was believed to be making good progress before he fell ill at his home.
Maradona's death was confirmed on the 15th anniversary of the passing of Northern Ireland and Manchester United legend George Best, who was often mentioned alongside Maradona as one of the game's most gifted performers.
The Argentine FA confirmed the news with a message on their Twitter account that read:
The Argentine Football Association, through its President Claudio Tapia, expresses its deepest sorrow for the death of our legend, Diego Armando Maradona. You will always be in our hearts.
Maradona is widely regarded as one of the greatest footballers of all time and was the inspiration for Argentina’s World Cup success in Mexico in 1986. He also led the country to the final of the 1990 tournament in Italy and managed them in South Africa in 2010.
The tributes were quick to pour in for a player respected as one of the game's all-time legends, with former England captain Gary Lineker among those offering words of sympathy.