The fiery Irishman’s time at United came to an untimely end in 2005 after his relationship with Red Devils icon Sir Alex Ferguson began to fall apart.
Keano had enjoyed an illustrious playing career at Old Trafford and lifted seven Premier League titles, a Champions League and four FA Cups but his explosive rant during his infamous MUTV appearance contributed to his exit.
He now says that he never warmed to Ferdinand, who was one of the players he called out, or Rooney, and didn’t understand their banter.
But the former United captain added that his stance towards Rooney and Ferdinand might have been a “personal thing.”
“Near the end, I remember thinking I don’t get some of the boys,” Keane told Sky Sports’ The Football Show.
“I didn’t get Wayne or Rio, I didn’t get their banter or what they stood for sometimes. I rarely had a conversation with anyone.
“When I left there were a lot of players I didn't miss. The game was changing and maybe I was a bit grumpy, a bit old school.
“Personality-wise they were not for me. Obviously, they were very good players and I was delighted to play with them but in terms of banter or having a cup of coffee with them? No, forget it.”
Keane admitted that he didn’t see eye to eye with Rooney off the field, but he insisted that he had a “lot of respect” for him and praised him as a “brilliant player.”
The Sky Sports pundit recalled an incident when Rooney changed the channel to put on The X Factor.
Keane said: “We certainly didn’t have an argument, let me tell you.
“I like my rugby league and yeah, someone did change the channel and I wasn’t happy.
“But we didn’t have an argument about it. I came down for breakfast the next day and Wayne said, ‘Did you find the control?’
“So, I told him where to go. If that’s an argument, God help us. I certainly didn’t respect Wayne because he stood up to me and wanted to watch the X Factor.
“I had a lot of respect for Wayne because I thought he was a brilliant player.
“I wouldn’t say I warmed to the guy, I certainly didn’t dislike him. But the lad’s on a different wavelength, different banter and if hiding the control was his type of banter then... not for me.”
Keane spent four seasons playing alongside Ferdinand and two seasons with Rooney before calling time on his United career.
His last trophy as captain came with the FA Cup win during the 2003/04 season, but before his departure in 2005 he had let his feelings be known about several teammates including Ferdinand as well as manager Sir Alex Ferguson.