Michael was told by doctors that he had young-onset Parkinson's disease in 1991 - when he was just 29-years-old.
And while he initially struggled with the news, he has been committed to campaigning for increased research into the disease for years.
Michael also underwent major surgery on his spine in 2018 to correct a problem with his spinal cord, with him having to learn to walk again.
And, just as he had recovered from that major surgery, he revealed how he shattered his arm during a fall in his kitchen.
As a result of his injuries he was forced to bring in home help to monitor him as he convalesced in his Beverly Hills home.
And the star (59), told Ryan Tubridy on the Late Late Show how two nurses from Galway, looked after him until he was able to walk again.
“They were amazing,” he said.
“My grandmother is from Belfast. They were from Galway, and had a different accent but similar in musicality and in tone.
“They were trying to keep me from walking too much, and I had difficulty walking.
“And I was walking my way through this room I had dedicated to convalescence at home.
“But if I stirred, they would get up.
“And one night I got up and swung my legs to get up and I just heard; ‘and where do you think you are going’.
“And it was like I could hear my grandmother. So, I swung my legs back into bed and said ‘nowhere’.
“But they were great and now, thank God, I am healthy.”
The Hollywood star also talked about his new book, No Time Like the Future, which features personal and moving moments including when he had to learn to talk again after an operation on his spine.
And he talked about his relationship with the temperamental Belfast made DeLorean car which featured in the three hit movies.