Speaking on his RTE Radio One show this morning, the presenter said that those who say they don't believe in the vaccine should be told to “get out, and you're not invited and you're disinvited because you're a greater risk to everyone else".
During a segment of the show Tubridy discussed how an emerging trend in the US sees wedding guests being asked to provide evidence of their vaccine status to attend the nuptials.
It was highlighted how some couples are planning on leaving unvaccinated friends or family members off the guest list, or hoping to set up mobile antigen testing sites the day before their weddings to provide a pandemic-free environment for the event.
"They're politely worded notes telling guests 'you must be vaccinated' or 'you have to get a Covid test' or both," he explained to his listeners.
"According to wedding planners over in the states, they're saying this is the new etiquette now. Couples are not shy about asking guests about their vaccination status."
While typical wedding protocol involves bringing a gift and not wearing white, now guests must consider their Covid health status too.
Tubs added: "This is what they're saying, because obviously they don't want to have a super spreader event, and they don't want somebody coming along with the mark of Cain going 'I don't believe in the vaccine' - well then get out, and you're not invited and you're disinvited because you're a greater risk to everyone else.
"They have to do it, and there are so few people who are against the vaccination thing now really, that it would be unusual to get a no, but in the states is 50/50 nearly."
He also considered that the pandemic will have caused some families to fall out due to the differing beliefs people can hold about the virus.
"I would imagine it causes great friction and arguments so I really wouldn't fancy having that problem,” he added.
“They don't want somebody coming along with the mark of Cain going 'I don't believe in the vaccine' - well then get out, and you're not invited and you're disinvited'.
While restrictions on weddings in Ireland have relaxed since the beginning of the pandemic, guest numbers are still limited as venues can only be filled to 60 per cent capacity.
Everyone attending an indoor event in Ireland must currently be fully vaccinated or have recovered from Covid-19 in the past six months.
In a survey of 1,400 couples last month, 22 per cent said they were requiring guests to be vaccinated at their wedding.