The occupants of the van, a man and woman in their 20s and a male infant, were taken to University Hospital Limerick for treatment but are believed to be uninjured at this time.
The road is currently closed for an examination by Forensic Collision Investigators and local Diversions are in place.
Gardaí in Limerick are appealing to any person who may have witnessed this collision to contact them. Any road users who were travelling in the area and who may have camera (including dash cam) footage is asked to make this available to investigating Gardaí.
Anyone with any information is asked to contact Henry Street Garda Station on 061 212 400, the Garda Confidential Line on 1800 666 111, or any garda station.