It's understood the woman was shot in the chest and the arm.
A man was also taken to hospital with gun shot injuries.
The scene of the shooting incident has been preserved for a technical examination and Gardai from Killmainham are investigating.
"Gardaí are investigating a shooting incident that occurred at an apartment in Bluebell, Dublin 8, this afternoon Saturday 6th March, 2021 at approximately 1p.m.," a Garda spokesperson said. in a statement this evening.
"A woman, aged in her 30s, received gunshot wounds and was removed to St. James Hospital in a serious condition.
"A short time later a man (early 30s) attended St. James Hospital with gunshots wounds. He is in a serious condition.
The Garda Forensic Investigators are currently at scene and a technical examination is taking place.
Gardaí are appealing for anyone with information in relation to this incident to come forward.
Anyone with any information in relation to this matter should contact Kevin Street Garda Station on 01 666 9400, the Garda Confidential Line on 1800 666 111 or any Garda station.
It's understood the female victim is known to real IRA killer Sean Connolly who is serving life for murdering veteran crime boss Eamon Kelly.
Kelly (65) was shot dead near his home as he returned home from a betting shop in December 2012.
Sean Connolly has been serving a life sentence since he pleaded guilty to the murder at the Special Criminal Court in April 2015.
Connolly had been charged at a special sitting of the non-jury court with the murder of Kelly at Furry Park Road, Killester, on 4 December 2012.
Connolly had also been charged with IRA membership and with possession of a firearm on the same occasion.
However, Connolly pleaded guilty to the murder of Kelly before his trial started and the court was told that the remaining two counts would proceed no further.