The UFC star has blasted the new rules and suggested Ireland should think about leaving the EU
The comments came as the Crumlin-born fighter blasted the government in a series of late night tweets.
In the posts, McGregor called for a conversation about Ireland to withdrawing from the EU and described the government as "lap dogs."
The ex-champion's social media tweets came after the government announced they were tightening the level of restrictions placed on hospitality in a bid to curb the spread of Covid-19.
The government's decision came after a number of EU states introduced mandatory vaccinations in response to the spread of the virus.
McGregor wrote: "Forcing anyone to inject something into their body they do not wish to is abhorrently wrong.
"I am not against vaccines, I am against not having the choice.
"God bless those who think otherwise."
Yesterday, Taoiseach Micheal Martin confirmed that new restrictions are to be introduced in pubs and restaurants - while the recommendations of household gatherings are also to be tightened.
However, McGregor blasted the new rules and suggested Ireland should think about leaving the EU.
He said: "Embarrassing "leadership". Messengers. Lap dogs. Get this system and shred it fully!
"Disband nphet. Realign the hse to do it's job. Formed 2005 to assist our hospitals. Instead annihilated. 11.5m public-funded hse money paid to media entities. This year alone. Appalling.
"To be at this level of vaccination % yet going backwards, and attempting now to talk mandating. Laughable.
"Shame on you all in current power. EU lackeys. The tracks of this gravy train will so be realigned and set to its rightful destination of an Irish red brick wall."
He added: "It is time to talk Ireland leaving the European Union."
"We do not have leaders in Ireland, we have messengers. Subordinates."
Last night's posts were not the first time McGregor has turned his attention to the government's response to Covid-19.
Earlier this week, he fire off a bizarre tweet saying:
"Unvaxx double vaxx scumbags! Dangers to society all of you! I blame you all when this takes hold,” he wrote in a new tweet today that has since been deleted.
The obscure message follows a stream of recent pot shots he has taken on social media in relation to many aspects of the pandemic including the government, and vaccines.
Last week the MMA fighter even took on a new Covid variant first detected in Botswana.
“Guys did you hear? We’ve to watch out for this Botswana yoke now,” he said in a tweet.
“It sounds serious,” he continued. “It’s not protected against our vaccines also. ‘Vaccine laughed at’ it said. Crazy! Chances of hitting the deck have now trebled again, so back in your box.”
“This message directly from Tony Baloni,” he said, taking a swipe at HSE Chief Medical officer Tony Holohan.
“Oh no! This Botswana is worse than the Delta!” he said in a follow up tweet, adding: “But trust me when I say, it's F**K ALL TO THE ALPHA! Oh yes!”
In a recent tirade the 33-year-old said that vaccines are not working.
“The vaccines have not worked to stop this whatsoever. More vaccinated than ever. More cases than ever. Re-evaluate entirely. Stop taking handouts,” he said in a now-deleted tweet.
But McGregor does not acknowledge that the aim of the vaccination rollout is to reduce hospitalisations, the severity of the infection if contracted, and deaths.
He replied to a tweet written by journalist Gavan Reilly which dismissed rumours that dates for a potential December lockdown were being discussed in Leinster House.
“An outlet is reporting some dates for prospective pub closures, and outright lockdown, based on suggestions from people ‘in Leinster House’. Worth remembering that Leinster House is not where such dates are decided, but Government Buildings. There’s no parliamentary role in it,” Gavan wrote.
“Yet leave the Dáil bar open. The hospitality sector is not a scapegoat, nor even the issue here. This sector has been closed. It is the incapacity to bolster our ability to house patients. There is no excuse for a LIFETIME OF NEGLIGENCE AND FAILURE TO FIX THIS. Will not comply!” McGregor responded in another deleted tweet.
Earlier this month he labelled Leo Varadkar as a “poisonous buffoon” after the Tánaiste appeared on American news network CNN to discuss Ireland’s surge of Covid cases.
“Poisonous individual! Buffoon. Get this blithering fool off my screen. Show pony phony,” McGregor said, sharing a clip of the programme.
The former Taoiseach said that the 5% of people in Ireland who are unvaccinated are “causing the trouble.”
He told the station’s news anchor that he hopes that the booster programme will help with waning immunity. He also said that he hope no new restrictions will be put in place before Christmas.
“Half a mil per annum our ‘chief’ is on. Not including perk. All I have seen from this individual is the same identical statement over and over and over again."
"Our healthcare is under strain," Conor added in another tweet.
"You are not paid to make this statement. You are paid to fix it. Do. Your. Job!”
“Who on earth do these lizards think they are? It is not just ‘necessary’ they pay.
"It is essential! Necessary after the light is shone, how convenient. Lizards,” he said, while quoting a tweet from journalist Gavan Reilly about TDs being offered free antigen tests.
He further proclaimed: “The unchecked goings on inside that house is horrid. The horrid house of the Oireachtas! I shout PETTY TREASON!”