Jose Mourinho confirms Marouane Fellaini start against Saints while Paul Pogba will not play
The France midfielder has been given an extended period away from first-team duties following the death of his father.
Pogba will not be part of the United squad to take on Claude Puel's Southampton side at St Mary's on Wednesday.
The Frenchman's father passed away last Friday, with the midfielder not part of the team that lost 2-1 to Tottenham at White Hart Lane on Sunday.
The belief is that Pogba will likely not return to the United squad for the club's final league tie against Crystal Palace but will be available for the Europa League final in Stockholm on May 24.
Meanwhile, Mourinho told reporters today that Daley Blind will be rested for the trip to the south coast but Maroune Fellaini will start against the Saints. The Belgian midfielder is returning from a three-match domestic suspension, having been sent off in the 0-0 draw against Manchester City for a headbutt on Sergio Aguero.
The Man Utd boss also stated that Sergio Romero will start one of the club's final two league games.
David de Gea's understudy has been Mourinho's regular Europa League keeper this season, with the Argentinean reportedly set to keep his starting berth ahead of the Spaniard for Wednesday week's final against Ajax.
On team selection, the Portuguese coach said: "I have to build some teams with the minimum of conditions to fight for the result. We lost against Arsenal 2-0, we fought for the result. We lost 2-1 against Tottenham and we fought for the result and we want to fight for the result.
"I don't want to field a team where people have a feeling that we are not fighting for the result. We are fighting for the result.
"I am going to rotate people. As I was saying Blind will not be playing against Southampton and Fellaini will because he's not played the last three matches and these are examples of trying not to accumulate when people have to play because we do not have other players and I cannot put four or five kids all together in the fire. I cannot do that to the kids."