Gardai in Newcastle West are investigating the fatal road traffic collision, which occurred on the N21 between Newcastle West and Rathkeale yesterday evening at approximately 6.30pm.
A female in her early 70s - who was a passenger in one of the cars - was fatally injured and pronounced dead at the scene.
All three drivers were taken to University Hospital Limerick with injuries described as minor.
The stretch of road is currently closed to facilitate an examination by Garda Forensic Collision Investigators and is expected to remain closed overnight. Local diversions are in place.
Garda wish to appeal for witnesses to contact Newcastle West Garda Station on 069- 20650, the Garda Confidential Telephone Line 1800 666 111 or any Garda Station.