Gardaí in Oranmore are investigating the fatal road traffic collision, which occurred on the N6 approximately three kilometres from Craughwell on the Oranmore to Craughwell Road this afternoon.
At approximately 4.20pm, a woman in her mid-50s was fatally injured when the car she was driving was involved in a collision with another car.
The woman, who was the sole occupant of the vehicle, was pronounced dead at the scene.
Emergency services were called and the three occupants of the other car were removed to University Hospital Galway with what is described as non-life threatening injuries.
The road is currently closed to facilitate Garda Forensic Collision Investigators. Local diversions are in place.
Gardaí are appealing for witnesses to the collision to contact them at Oranmore Garda Station on 091-388 030, the Garda Confidential Line 1800 666111 or any Garda Station.