As a result of an intelligence led operation, members of the Drugs and Organised Crime Bureau, assisted by the Emergency Response Unit and national units, stopped and searched a car on Clonshaugh Avenue in Coolock this afternoon.
During the course of the search Gardaí seized two firearms - subject to analysis - and arrested the driver. Simultaneously, a van was stopped by Gardai on nearby Clonshaugh Road and a man was arrested.
The two men, aged 39 and 44, are currently detained at Coolock Garda Station under Section 30 of the Offences Against the State Act, 1939.
Investigations are ongoing.
The seizure comes less than two days after the latest gangland murder to rock the country.
Father-of-two Alan O'Neill was gunned down in Tallaght on Wednesday night. O'Neill was shot several times shortly after returning to his home at Kiltalown Road at around 10.30pm.
The handgun used in the shooting has not been recovered and the hitman is said to still be at large.
This is the second murder in the capital in less than a week, after the remains of Andrew Guerrine were found on Steelstown Lane, near Rathcoole.