As part of an ongoing operation into the illegal sale and supply of controlled drugs in the County Offaly area, Gardaí from Edenderry carried out the planned search of a premises at Clonmore on Wednesday.
During the late-night raid, Gardai seized cannabis plants with an estimated value of €250,000, pending analysis.
Yesterday, officers from Edenderry - assisted by Gardaí from the Tullamore District Drugs Unit - stopped and searched a vehicle close to Tullamore and seized a quantity of cannabis plants.
In a follow up search of a premises at Killy, Tullamore Gardaí seized more cannabis plants with an estimated value of €160,000.
Two men - aged 26 and 30 years - were arrested and are currently detained at Tullamore Garda Station under Section 2 of the Criminal Justice (Drug Trafficking) Act, 1996.